Of course! That little metaphysical ball of smoke knows no bounds and takes no prisoners! It’s time to be the big one for once and raise some mayhem.

Now just think of those exorcisms.

Ut Ecclesiam tuam secura tibi facias libertate servirete rogamus, audi nos! 

*Person coughs up tiny puff of smoke*

“Did you get it all? Do we need to say it again?”

*Tosses holy water on the befuddled person*

Maybe. Or maybe if one of Sam’s people makes a deal or just plain goes to hell, they become demons too, so you have itty bitty black smoke clouds looking for a host.

And angels do not have a problem with any size host. When you’re the size of the Chrysler building, a few more feet won’t hurt to smoosh into.