I have a feeling those little guys would end up with pie, but they’d get out of the room as fast as possible regardless. It’s dangerous to be around any humans, and they might seem friendly, but it’s better to be safe than sorry.
None of that would stop Dean from coming back to their room later on and demanding an explanation for all of it. How do they know about little people like him? Do they plan on trying to find anyone else in the motel?
He’d want to make sure the others at the motel weren’t in any danger before letting his guard down.
You can count canon Jacob in with the friendly humans too. Bowman has bopped those lessons into his head many times. We’ll just have to see if Sam and Dean do the same with Jacob the drifter.