Only as much as full sized Sam is larger and stronger than his older brother!

On the same size scale, the brothers are as equal as they are in canon. Both receive the strength boon that borrowers get.

Compared to a human at the same size, they’re both around 12 to 13x stronger. With training and proper nutrition, they’ll be closer to 17x their regular strength. So if Dean wanted to, he could dangle Sam by the nape of his neck just as much as Sam does.

He just happens to be shorter, so it’s nowhere near as easy, ffs. Stop that, Sam!